Article
Long-Term Effects of Prenatal Hypoxia on Schizophrenia-Like Phenotype in Heterozygous Reeler Mice.
Molecular neurobiology - 1 Jul 2016
Howell Kristy R, Pillai Anilkumar
Abstract excerpt
Prenatal hypoxia (PHX) is a well-known environmental factor implicated in the pathophysiology of schizophrenia. However, the long-term effects of PHX on schizophrenia-related neuroplasticity are poorly understood. Using behavioral tasks, MRI imaging, and biochemical studies, we examined the long-term effects of PHX in heterozygous reeler mice (HRM; mice deficient for reelin, a candidate gene for schizophrenia)....
Topics
- Animals
- Behavior, Animal
- Corticosterone
- Heterozygote
- Hippocampus
- Hypoxia
- Maze Learning
- Mice, Neurologic Mutants
- Phenotype
- Prepulse Inhibition
- Receptors, Glucocorticoid