Article
Heterozygous reeler mice exhibit alterations in sensorimotor gating but not presynaptic proteins.
The European journal of neuroscience - 1 May 2008
Barr Alasdair M, Fish Kenneth N, Markou Athina, Honer William G
Abstract excerpt
Post mortem, reduced brain reelin is noted in schizophrenia. Accordingly, the reelin-haploinsufficient heterozygous reeler mouse (HRM) has been posited as a murine model of the illness. One study reported that HRM exhibit deficits in prepulse inhibition (PPI) of the acoustic startle reflex, a sensorimotor-gating behavior that is disrupted in schizophrenia, although this finding has not been reproduced. To extend...
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