Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction.

doi:10.1016/j.bbi.2012.02.010

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Article

Phenotypic effects of repeated psychosocial stress during adolescence in mice mutant for the schizophrenia risk gene neuregulin-1: a putative model of gene × environment interaction.

Brain, behavior, and immunity - 1 May 2012

Desbonnet Lieve, O'Tuathaigh Colm, Clarke Gerard, O'Leary Claire, Petit Emilie, Clarke Niamh, Tighe Orna, Lai Donna, Harvey Richard, Cryan John F, Dinan Timothy G, Waddington John L

Abstract excerpt

There is a paucity of animal models by which the contributions of environmental and genetic factors to the pathobiology of psychosis can be investigated. This study examined the individual and combined effects of chronic social stress during adolescence and deletion of the schizophrenia risk gene neuregulin-1 (NRG1) on adult mouse phenotype. Mice were exposed to repeated social defeat stress during adolescence...

Topics

Animals
Brain-Derived Neurotrophic Factor
Corticosterone
Cytokines
Disease Models, Animal
Environment
Exploratory Behavior
Gene-Environment Interaction
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Neuregulin-1

Phenotype

Schizophrenia

Schizophrenic Psychology

Social Behavior

Stress, Psychological

Source

Open in PubMed

Identifiers

PMID: 22426432
DOI: 10.1016/j.bbi.2012.02.010

Genes

NRG1
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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