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Article

Crystallization of interleukin-18 for structure-based inhibitor design.

Acta crystallographica. Section F, Structural biology communications - 1 Jun 2015

Krumm Brian, Meng Xiangzhi, Xiang Yan, Deng Junpeng

Abstract excerpt

Interleukin-18 (IL-18) is a pleiotropic pro-inflammatory cytokine belonging to the IL-1 superfamily. IL-18 plays an important role in host innate and acquired immune defense, with its activity being modulated in vivo by its naturally occurring antagonist IL-18 binding protein (IL-18BP). Recent crystal structures of human IL-18 (hIL-18) in complex with its antagonist or cognate receptor(s) have revealed a...

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Identifiers

PMID: 26057800
DOI: 10.1107/S2053230X15006871
PMCID: PMC4461335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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