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Predicted IL-18/IL-18R Binding Improvement Through Protein Interface Modification with Computer-Aided Design.

Biomolecules - 25 Sept 2025

Prompat Napat, Peeyatu Chariya, Saetang Jirakrit, Roongsawang Niran, Sangkhathat Surasak, Tipmanee Varomyalin

Abstract excerpt

Cytokine-mediated immunotherapy has rapidly emerged as an effective alternative approach for cancer treatment by modulating the anti-tumor response. Interleukin-18 (IL-18) is considered as a promising cancer therapeutic agent due to the ability of cytokines to inhibit cancer by enhancing natural killer (NK) cell and cytotoxic T cell responses. Since the activity of IL-18 is required for the specific binding to...

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PMID: 41154589
DOI: 10.3390/biom15101360
PMCID: PMC12564372

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