Article
Inhibiting protein-protein interactions: a model for antagonist design.
Biochemistry - 20 Jun 2000
Chrunyk B A, Rosner M H, Cong Y, McColl A S, Otterness I G, Daumy G O
Abstract excerpt
Protein-protein interactions (PPI) are a ubiquitous mode of transmitting signals in cells and tissues. We are testing a stepwise, generic, structure-driven approach for finding low molecular weight inhibitors of protein-protein interactions. The approach requires development of a high-affinity, single chain antibody directed specifically against the interaction surface of one of the proteins to obtain structural...
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