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Article

Unveiling novel insights into human IL-6 - IL-6R interaction sites through 3D computer-guided docking and systematic site mutagenesis.

Scientific reports - 7 Aug 2024

Li Kaitong, Cai Junyu, Jiang Zhiyang, Meng Qingbin, Meng Zhao, Xiao He, Chen Guojiang, Qiao Chunxia, Luo Longlong, Yu Jijun, Li Xinying, Wei Yinxiang, Li Hui, Liu Chenghua, Shen Beifen, Wang Jing, Feng Jiannan

Abstract excerpt

The cytokine interleukin-6 (IL-6) plays a crucial role in autoimmune and inflammatory diseases. Understanding the precise mechanism of IL-6 interaction at the amino acid level is essential to develop IL-6-inhibiting compounds. In this study, we employed computer-guided drug design tools to predict the key residues that are involved in the interaction between IL-6 and its receptor IL-6R. Subsequently, we generated...

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Identifiers

PMID: 39112658
DOI: 10.1038/s41598-024-69429-w
PMCID: PMC11306327

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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