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Article

Engineering human IL-18 with increased bioactivity and bioavailability.

Cytokine - 1 Apr 2006

Swencki-Underwood Bethany, Cunningham Mark R, Heavner George A, Blasie Cheryl, McCarthy Stephen G, Dougherty Tara, Brigham-Burke Mike, Gunn George R, Goletz Theresa J, Snyder Linda A

Abstract excerpt

Cytokines in plasmid form can act as potent adjuvants when co-administered with DNA vaccines, resulting in an enhanced immune response to the DNA-encoded antigen. This is true of interleukin-18 (IL-18), which has been shown to serve as an adjuvant in conjunction with certain DNA vaccines. To determine if the properties of IL-18 could be optimized for use as a DNA vaccine adjuvant, a model of IL-18/IL-18R binding...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

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Source

Identifiers

PMID: 16750378
DOI: 10.1016/j.cyto.2006.04.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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