Article
It's all in the crystals….
Acta crystallographica. Section D, Biological crystallography - 1 Apr 2011
Derewenda Zygmunt S
Abstract excerpt
Macromolecular crystallography relies on the availability and quality of single crystals; these are typically obtained through extensive screening, which has a very low intrinsic success rate. Crystallization is not a completely stochastic process and many proteins do not succumb to crystallization because of specific microscopic features of their molecular surfaces. It follows that rational surface engineering...
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