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Article

Flexible regions govern promiscuous binding of IL ‐24 to receptors IL ‐20R1 and IL ‐22R1

1 Jun 2019

Abstract excerpt

Interleukin 24 (IL-24) is a cytokine with the potential to be an effective treatment for autoimmune diseases and cancer. However, its instability and difficulties in its production have hampered detailed biological and biophysical studies. We approached the challenges of IL-24 production by using the PROSS algorithm to design more stable variants of IL-24. We used homology models built from the sequences and...

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PMID: 31152679
DOI: 10.1111/febs.14945

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