Article
Role of Non-Binding T63 Alteration in IL-18 Binding.
International journal of molecular sciences - 3 Dec 2024
Peeyatu Chariya, Prompat Napat, Voravuthikunchai Supayang Piyawan, Roongsawang Niran, Sangkhathat Surasak, Khongkow Pasarat, Saetang Jirakrit, Tipmanee Varomyalin
Abstract excerpt
Engineered interleukin-18 (IL-18) has attracted interest as a cytokine-based treatment. However, knowledge-based mutagenesis of IL-18 has been reported for only a few regions of the protein structures, including binding sites I and II. When coupled with the binding region mutant (E6K), the non-binding residue of IL-18, Thr63 (T63), has been shown to increase the flexibility of the binding loop. Nevertheless, the...
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