Article
The structural basis for receptor recognition of human interleukin-18.
Nature communications - 15 Dec 2014
Tsutsumi Naotaka, Kimura Takeshi, Arita Kyohei, Ariyoshi Mariko, Ohnishi Hidenori, Yamamoto Takahiro, Zuo Xiaobing, Maenaka Katsumi, Park Enoch Y, Kondo Naomi, Shirakawa Masahiro, Tochio Hidehito, Kato Zenichiro
Abstract excerpt
Interleukin (IL)-18 is a proinflammatory cytokine that belongs to the IL-1 family and plays an important role in inflammation. The uncontrolled release of this cytokine is associated with severe chronic inflammatory disease. IL-18 forms a signalling complex with the IL-18 receptor α (Rα) and β (Rβ) chains at the plasma membrane, which induces multiple inflammatory cytokines. Here, we present a crystal structure...
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