Article
Angiotensin II type 2 receptor- and acetylcholine-mediated relaxation: essential contribution of female sex hormones and chromosomes.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 2015
Pessôa Bruno Sevá, Slump Denise E, Ibrahimi Khatera, Grefhorst Aldo, van Veghel Richard, Garrelds Ingrid M, Roks Anton J M, Kushner Steven A, Danser A H Jan, van Esch Joep H M
Abstract excerpt
Angiotensin-induced vasodilation, involving type 2 receptor (AT2R)-induced generation of nitric oxide (NO; by endothelial NO synthase) and endothelium-derived hyperpolarizing factors, may be limited to women. To distinguish the contribution of female sex hormones and chromosomes to AT2R function and endothelium-derived hyperpolarizing factor-mediated vasodilation, we made use of the four-core genotype model,...
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