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Article

The number of X chromosomes influences protection from cardiac ischaemia/reperfusion injury in mice: one X is better than two

19 Mar 2014

Abstract excerpt

AIM: Sex differences in coronary heart disease have been attributed to sex hormones, whereas the potential role of the sex chromosomes has been ignored so far. Here, we investigated the role of the sex chromosomes in causing sex differences in myocardial ischaemia/reperfusion (I/R) injury. METHODS AND RESULTS: We used two unique mouse models, the 'four core genotypes' [XX mice with ovaries (XXF) or testes (XXM)...

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Share to Cardiovascular, Neuropeptides, and Oxidative Stress Research
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Identifiers

PMID: 24654234
DOI: 10.1093/cvr/cvu064

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