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Article

Sex chromosomes and cardiovascular disease.

European journal of preventive cardiology - 18 Feb 2026

Spiering Anna E, Groenheide Phebe J, Mokry Michal, Onland-Moret N Charlotte, Civelek Mete, Reue Karen, Diez Benavente Ernest, den Ruijter Hester M

Abstract excerpt

Sex differences in cardiovascular disease (CVD) are increasingly recognized. These are traditionally attributed to hormonal influences, but recent evidence underscores the potential role of sex chromosomes. This review describes the involvement of sex chromosomes in CVD, through loss of chromosomes, genetic variation, and altered expression. Mosaic loss of the Y chromosome (mLoY) is the most well-characterized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40231569
DOI: 10.1093/eurjpc/zwaf224

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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