Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sex differences in ischemic stroke sensitivity are influenced by gonadal hormones, not by sex chromosome complement.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Feb 2015

Manwani Bharti, Bentivegna Kathryn, Benashski Sharon E, Venna Venugopal Reddy, Xu Yan, Arnold Arthur P, McCullough Louise D

Abstract excerpt

Epidemiologic studies have shown sex differences in ischemic stroke. The four core genotype (FCG) mouse model, in which the testes determining gene, Sry, has been moved from Y chromosome to an autosome, was used to dissociate the effects of sex hormones from sex chromosome in ischemic stroke outcome. Middle cerebral artery occlusion (MCAO) in gonad intact FCG mice revealed that gonadal males (XXM and XYM) had...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Mammalian
Share to Estrogens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gonadal Dysgenesis

Share to Infarction, Middle Cerebral Artery

Share to Sex-Determining Region Y Protein

Share to Stroke

Share to X Chromosome

Share to Y Chromosome

Source

Open in PubMed Open full text

Identifiers

PMID: 25388681
DOI: 10.1038/jcbfm.2014.186
PMCID: PMC4426738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sex differences in ischemic stroke sensitivity are influenced by gonadal hormones, not by sex chromosome complement.PMID 25388681Read ↗

Stroke sensitivity in the aged: sex chromosome complement vs. gonadal hormones.Semantic proximity Read ↗

X, but not Y, Chromosomal Complement Contributes to Stroke Sensitivity in Aged Animals.Semantic proximity Read ↗

Sex chromosome complement interacts with gonadal hormones in determining regional-specific neuroactive steroid levels in plasma, hippocampus, and hypothalamus. A study using the four core genotype mouse model.Semantic proximity Read ↗

Sex-Specific Acute Cerebrovascular Responses to Photothrombotic Stroke in Mice.Semantic proximity Read ↗

Mouse models for evaluating sex chromosome effects that cause sex differences in non-gonadal tissues.Semantic proximity Read ↗

Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for therapeutic interventionsSemantic proximity Read ↗

Sex Hormones and Sex Chromosomes Cause Sex Differences in the Development of Cardiovascular Diseases.Semantic proximity Read ↗

Sry-modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and more.Semantic proximity Read ↗

<i>Sry</i> -modified laboratory rat lines to study sex-chromosome effects underlying sex differences in physiology and disease: Four Core Genotypes and moreSemantic proximity Read ↗

Angiotensin II type 2 receptor- and acetylcholine-mediated relaxation: essential contribution of female sex hormones and chromosomes.Semantic proximity Read ↗

Sex in basic research: concepts in the cardiovascular field.Semantic proximity Read ↗

Genetically predicted high serum sex hormone-binding globulin levels are associated with lower ischemic stroke risk: A sex-stratified Mendelian randomization study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.