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Article

Sex chromosome complement involvement in angiotensin receptor sexual dimorphism.

Molecular and cellular endocrinology - 15 May 2017

Dadam Florencia M, Cisternas Carla D, Macchione Ana F, Godino Andrea, Antunes-Rodrigues José, Cambiasso María J, Vivas Laura M, Caeiro Ximena E

Abstract excerpt

This study aimed to define whether sex chromosome complement (SCC) may differentially modulate sex differences in relative gene expression of basal Agtr1a, Agtr2, and Mas1 receptors at fore/hindbrain nuclei and at medulla/cortical kidney. Samples were collected from gonadectomized male (XX and XY) and female (XX and XY) mice of the "four core genotypes" model. At brain level, a SCC effect at the area postrema was...

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PMID: 28254489
DOI: 10.1016/j.mce.2017.02.041

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