Article
Senescence and entrenchment in evolution of amino acid sites.
Nature communications - 14 Sept 2020
Stolyarova A V, Nabieva E, Ptushenko V V, Favorov A V, Popova A V, Neverov A D, Bazykin G A
Abstract excerpt
Amino acid propensities at a site change in the course of protein evolution. This may happen for two reasons. Changes may be triggered by substitutions at epistatically interacting sites elsewhere in the genome. Alternatively, they may arise due to environmental changes that are external to the genome. Here, we design a framework for distinguishing between these alternatives. Using analytical modelling and...
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