Reconstitution of local Ca2+ signaling between cardiac L-type Ca2+ channels and ryanodine receptors: insights into regulation by FKBP12.6.

doi:10.1152/ajpcell.00250.2005

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Article

Reconstitution of local Ca2+ signaling between cardiac L-type Ca2+ channels and ryanodine receptors: insights into regulation by FKBP12.6.

American journal of physiology. Cell physiology - 1 Dec 2005

Goonasekera Sanjeewa A, Chen S R Wayne, Dirksen Robert T

Abstract excerpt

Ca+-induced Ca2+ release (CICR) in the heart involves local Ca2+ signaling between sarcolemmal L-type Ca2+ channels (dihydropyridine receptors, DHPRs) and type 2 ryanodine receptors (RyR2s) in the sarcoplasmic reticulum (SR). We reconstituted cardiac-like CICR by expressing a cardiac dihydropyridine-insensitive (T1066Y/Q1070M) alpha1-subunit (alpha1CYM) and RyR2 in myotubes derived from RyR1-knockout (dyspedic)...

Topics

Animals
Animals, Newborn
Calcium Channels, L-Type
Calcium Signaling
Cells, Cultured
Electric Stimulation
Mice
Mice, Knockout
Muscle Contraction
Muscle Fibers, Skeletal
Muscle, Skeletal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Myocardium

Phosphorylation

Protein Subunits

Ryanodine Receptor Calcium Release Channel

Tacrolimus Binding Protein 1A

Tacrolimus Binding Proteins

Source

Open in PubMed

Identifiers

PMID: 16049053
DOI: 10.1152/ajpcell.00250.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Reconstitution of local Ca2+ signaling between cardiac L-type Ca2+ channels and ryanodine receptors: insights into regulation by FKBP12.6.PMID 16049053Read ↗

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