Article
A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia.
Cell - 14 Dec 2001
Kuo H C, Cheng C F, Clark R B, Lin J J, Lin J L, Hoshijima M, Nguyêñ-Trân V T, Gu Y, Ikeda Y, Chu P H, Ross J, Giles W R, Chien K R
Abstract excerpt
KChIP2, a gene encoding three auxiliary subunits of Kv4.2 and Kv4.3, is preferentially expressed in the adult heart, and its expression is downregulated in cardiac hypertrophy. Mice deficient for KChIP2 exhibit normal cardiac structure and function but display a prolonged elevation in the ST segment on the electrocardiogram. The KChIP2(-/-) mice are highly susceptible to the induction of cardiac arrhythmias....
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