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Article

Ryanodine receptor mutations in arrhythmias: advances in understanding the mechanisms of channel dysfunction.

Biochemical Society transactions - 1 Nov 2007

Thomas N L, George C H, Williams A J, Lai F A

Abstract excerpt

The cardiac ryanodine receptor (RyR2) mediates rapid Ca(2+) efflux from intracellular stores to effect myocyte contraction during the process of EC (excitation-contraction) coupling. It is now known that mutations in this channel perturb Ca(2+) release function, leading to triggered arrhythmias that may cause SCD (sudden cardiac death). Resolving the precise molecular mechanisms by which SCD-linked RyR2...

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Share to Arrhythmias, Cardiac
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17956252
DOI: 10.1042/BST0350946

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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