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Article

Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice.

Journal of cardiovascular electrophysiology - 1 Aug 2014

Grubb Søren, Speerschneider Tobias, Occhipinti Dona, Fiset Céline, Olesen Søren-Peter, Thomsen Morten B, Calloe Kirstine

Abstract excerpt

INTRODUCTION: KV 4 together with KV Channel-Interacting Protein 2 (KChIP2) mediate the fast recovering transient outward potassium current (I(to,f)) in the heart. KChIP2 is downregulated in human heart failure (HF), potentially underlying the loss of I(to,f). We investigated remodeling associated with HF hypothesizing that KChIP2 plays a central role in the modulation of outward K(+) currents in HF. METHODS AND...

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Identifiers

PMID: 24678923
DOI: 10.1111/jce.12422

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