Article
KChIP2 modulates the cell surface expression of Kv 1.5-encoded K(+) channels.
Journal of molecular and cellular cardiology - 1 Jul 2005
Li Huilin, Guo Weinong, Mellor Rebecca L, Nerbonne Jeanne M
Abstract excerpt
The Kv channel interacting proteins (KChIPs) were identified in a yeast two hybrid screen using the N terminus of Kv4.3 as bait. Previous studies have demonstrated that KChIP2 associates with voltage-gated K(+) (Kv) pore-forming (alpha) subunits of the Kv4 subfamily and contributes to the formation of the rapidly inactivating and recovering Kv4-encoded cardiac transient outward K(+) channels, I(to,f). Here, we...
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