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Article

Structural and functional analysis of LIM domain-dependent recruitment of paxillin to αvβ3 integrin-positive focal adhesions.

Communications biology - 29 Mar 2021

Ripamonti Marta, Liaudet Nicolas, Azizi Latifeh, Bouvard Daniel, Hytönen Vesa P, Wehrle-Haller Bernhard

Abstract excerpt

The LIM domain-dependent localization of the adapter protein paxillin to β3 integrin-positive focal adhesions (FAs) is not mechanistically understood. Here, by combining molecular biology, photoactivation and FA-isolation experiments, we demonstrate specific contributions of each LIM domain of paxillin and reveal multiple paxillin interactions in adhesion-complexes. Mutation of β3 integrin at a putative paxillin...

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Share to Fluorescence Recovery After Photobleaching
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33782527
DOI: 10.1038/s42003-021-01886-9
PMCID: PMC8007706

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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