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Article

Spatial and Temporal Regulation of Focal Adhesion Kinase Activity in Living Cells

29 Oct 2007

Abstract excerpt

Focal adhesion kinase (FAK) is an essential kinase that regulates developmental processes and functions in the pathology of human disease. An intramolecular autoinhibitory interaction between the FERM and catalytic domains is a major mechanism of regulation. Based upon structural studies, a fluorescence resonance energy transfer (FRET)-based FAK biosensor that discriminates between autoinhibited and active...

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Identifiers

PMID: 17967873
DOI: 10.1128/mcb.01324-07

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