Article
Molecular motion and tridimensional nanoscale localization of kindlin control integrin activation in focal adhesions.
Nature communications - 25 May 2021
Orré Thomas, Joly Adrien, Karatas Zeynep, Kastberger Birgit, Cabriel Clément, Böttcher Ralph T, Lévêque-Fort Sandrine, Sibarita Jean-Baptiste, Fässler Reinhard, Wehrle-Haller Bernhard, Rossier Olivier, Giannone Grégory
Abstract excerpt
Focal adhesions (FAs) initiate chemical and mechanical signals involved in cell polarity, migration, proliferation and differentiation. Super-resolution microscopy revealed that FAs are organized at the nanoscale into functional layers from the lower plasma membrane to the upper actin cytoskeleton. Yet, how FAs proteins are guided into specific nano-layers to promote interaction with given targets is unknown....
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