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Article

Multiparametric analysis of focal adhesion formation by RNAi-mediated gene knockdown

10 Aug 2009

Abstract excerpt

Cell adhesion to the extracellular matrix is mediated by elaborate networks of multiprotein complexes consisting of adhesion receptors, cytoskeletal components, signaling molecules, and diverse adaptor proteins. To explore how specific molecular pathways function in the assembly of focal adhesions (FAs), we performed a high-throughput, high-resolution, microscopy-based screen. We used small interfering RNAs...

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PMID: 19667130
DOI: 10.1083/jcb.200901105

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