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Article

The role of integrin-linked kinase in the molecular architecture of focal adhesions

1 Jan 2013

Abstract excerpt

Integrin-mediated focal adhesions (FAs) are large, multi-protein complexes that link the actin cytoskeleton to the extracellular matrix and take part in adhesion-mediated signaling. These adhesions are highly complex and diverse at the molecular level; thus, assigning particular structural or signaling functions to specific components is highly challenging. Here, we combined functional, structural and biophysical...

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PMID: 23843624
DOI: 10.1242/jcs.120295

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