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Article

Assembly of IFT trains at the ciliary base depends on IFT74.

Current biology : CB - 15 Jun 2015

Brown Jason M, Cochran Deborah A, Craige Branch, Kubo Tomohiro, Witman George B

Abstract excerpt

Intraflagellar transport (IFT) moves IFT trains carrying cargoes from the cell body into the flagellum and from the flagellum back to the cell body. IFT trains are composed of complexes IFT-A and IFT-B and cargo adaptors such as the BBSome. The IFT-B core proteins IFT74 and IFT81 interact directly through central and C-terminal coiled-coil domains, and recently it was shown that the N termini of these proteins...

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Source

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Identifiers

PMID: 26051893
DOI: 10.1016/j.cub.2015.04.060
PMCID: PMC4482480

Genes

IFT74
IFT81

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Assembly of IFT trains at the ciliary base depends on IFT74.PMID 26051893Read ↗

Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin.Semantic proximity Read ↗

IFT-81 and IFT-74 are required for intraflagellar transport in C. elegans.Semantic proximity Read ↗

IFT57 stabilizes the assembled intraflagellar transport complex and mediates transport of motility-related flagellar cargo.Semantic proximity Read ↗

Architecture of the IFT ciliary trafficking machinery and interplay between its componentsSemantic proximity Read ↗

Ciliary protein trafficking mediated by IFT and BBSome complexes with the aid of kinesin-2 and dynein-2 motorsSemantic proximity Read ↗

Tetrahymena IFT122A is not essential for cilia assembly but plays a role in returning IFT proteins from the ciliary tip to the cell body.Semantic proximity Read ↗

The <i>Chlamydomonas reinhardtii</i> BBSome is an IFT cargo required for export of specific signaling proteins from flagellaSemantic proximity Read ↗

Direct interactions of intraflagellar transport complex B proteins IFT88, IFT52, and IFT46.Semantic proximity Read ↗

Functional exploration of the IFT-A complex in intraflagellar transport and ciliogenesis.Semantic proximity Read ↗

Intraflagellar transport: from molecular characterisation to mechanismSemantic proximity Read ↗

Intraflagellar transport (IFT) protein IFT25 is a phosphoprotein component of IFT complex B and physically interacts with IFT27 in Chlamydomonas.Semantic proximity Read ↗

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