Article
The <i>Chlamydomonas reinhardtii</i> BBSome is an IFT cargo required for export of specific signaling proteins from flagella
28 Dec 2009
Abstract excerpt
In humans, seven evolutionarily conserved genes that cause the cilia-related disorder Bardet-Biedl syndrome (BBS) encode proteins that form a complex termed the BBSome. The function of the BBSome in the cilium is not well understood. We purified a BBSome-like complex from Chlamydomonas reinhardtii flagella and found that it contains at least BBS1, -4, -5, -7, and -8 and undergoes intraflagellar transport (IFT) in...
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