Article
Functional exploration of the IFT-A complex in intraflagellar transport and ciliogenesis.
PLoS genetics - 1 Feb 2017
Zhu Bing, Zhu Xin, Wang Limei, Liang Yinwen, Feng Qianqian, Pan Junmin
Abstract excerpt
Intraflagellar transport (IFT) particles or trains are composed of IFT-A and IFT-B complexes. To assess the working mechanism of the IFT-A complex in IFT and ciliogenesis, we have analyzed ift43 mutants of Chlamydomnonas in conjunction with mutants of the other IFT-A subunits. An ift43 null mutant or a mutant with a partial deletion of the IFT43 conserved domain has no or short flagella. The mutants accumulate...
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