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Article

IFT-81 and IFT-74 are required for intraflagellar transport in C. elegans.

Genes to cells : devoted to molecular & cellular mechanisms - 1 May 2007

Kobayashi Tetsuo, Gengyo-Ando Keiko, Ishihara Takeshi, Katsura Isao, Mitani Shohei

Abstract excerpt

Intraflagellar transport (IFT) is essential machinery for biogenesis and maintenance of cilia in many eukaryotic and prokaryotic cells. A large number of polypeptides are known to be involved in IFT, but the physiological role of each component is not fully elucidated. Here, we identified a C. elegans orthologue of a Chlamydomonas reinhardtii IFT component, IFT-81, and found that its loss-of-function mutants show...

Topics

Animals
Animals, Genetically Modified
Biological Transport, Active
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Carrier Proteins
Chemotaxis
Cilia
Flagella
Genes, Helminth
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neurons, Afferent

Phenotype

Source

Identifiers

PMID: 17535250
DOI: 10.1111/j.1365-2443.2007.01076.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17535250-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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IFT-81 and IFT-74 are required for intraflagellar transport in C. elegans.PMID 17535250Read ↗

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Together, the IFT81 and IFT74 N-termini form the main module for intraflagellar transport of tubulin.Semantic proximity Read ↗

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