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Article

HLTF's Ancient HIRAN Domain Binds 3' DNA Ends to Drive Replication Fork Reversal.

Molecular cell - 18 Jun 2015

Kile Andrew C, Chavez Diana A, Bacal Julien, Eldirany Sherif, Korzhnev Dmitry M, Bezsonova Irina, Eichman Brandt F, Cimprich Karlene A

Abstract excerpt

Stalled replication forks are a critical problem for the cell because they can lead to complex genome rearrangements that underlie cell death and disease. Processes such as DNA damage tolerance and replication fork reversal protect stalled forks from these events. A central mediator of these DNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26051180
DOI: 10.1016/j.molcel.2015.05.013
PMCID: PMC4475461

Genes

HLTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-26051180-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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