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Coordinated protein and DNA remodeling by human HLTF on stalled replication fork

27 Jul 2011

Abstract excerpt

Human helicase-like transcription factor (HLTF) exhibits ubiquitin ligase activity for proliferating cell nuclear antigen (PCNA) polyubiquitylation as well as double-stranded DNA translocase activity for remodeling stalled replication fork by fork reversal, which can support damage bypass by template switching. However, a stalled replication fork is surrounded by various DNA-binding proteins which can inhibit the...

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PMID: 21795603
DOI: 10.1073/pnas.1101951108

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