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Role of Double-Stranded DNA Translocase Activity of Human HLTF in Replication of Damaged DNA

30 Nov 2009

Abstract excerpt

Unrepaired DNA lesions can block the progression of the replication fork, leading to genomic instability and cancer in higher-order eukaryotes. In Saccharomyces cerevisiae, replication through DNA lesions can be mediated by translesion synthesis DNA polymerases, leading to error-free or error-prone damage bypass, or by Rad5-mediated template switching to the sister chromatid that is inherently error free. While...

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PMID: 19948885
DOI: 10.1128/mcb.00863-09

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