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Human HELQ regulates DNA end resection at DNA double-strand breaks and stalled replication forks

28 Oct 2023

Abstract excerpt

Following a DNA double strand break (DSB), several nucleases and helicases coordinate to generate single-stranded DNA (ssDNA) with 3' free ends, facilitating precise DNA repair by homologous recombination (HR). The same nucleases can act on stalled replication forks, promoting nascent DNA degradation and fork instability. Interestingly, some HR factors, such as CtIP and BRCA1, have opposite regulatory effects on...

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PMID: 37897354
DOI: 10.1093/nar/gkad940

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