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Article

Distinct roles of the two BRCA2 DNA-binding domains in DNA damage repair and replication fork preservation.

Cell reports - 27 May 2025

Neal Francisco E, Li Wenjing, Uhrig Mollie E, Katz Jeffrey N, Syed Shahrez, Sharma Neelam, Dutta Arijit, Burma Sandeep, Hromas Robert, Mazin Alexander V, Dray Eloise, Libich David S, Olsen Shaun K, Wasmuth Elizabeth V, Zhao Weixing, Sørensen Claus S, Wiese Claudia, Kwon Youngho, Sung Patrick

Abstract excerpt

Homologous recombination (HR) removes DNA double-strand breaks (DSBs) and preserves stressed DNA replication forks. Successful HR execution requires the tumor suppressor BRCA2, which harbors distinct DNA-binding domains (DBDs): one that possesses three oligonucleotide/oligosaccharide-binding (OB) folds (OB-DBD) and another residing in the C-terminal recombinase binding domain (CTRB-DBD). Here, we employ...

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Share to BRCA2 Protein
Share to DNA Breaks, Double-Stranded

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40323719
DOI: 10.1016/j.celrep.2025.115654
PMCID: PMC12129652

Genes

BRCA2
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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