Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disparate requirements for RAD54L in replication fork reversal

13 Sept 2024

Abstract excerpt

RAD54L is a DNA motor protein with multiple roles in homologous recombination DNA repair. In vitro, RAD54L was shown to also catalyze the reversal and restoration of model replication forks. In cells, however, little is known about how RAD54L may regulate the dynamics of DNA replication. Here, we show that RAD54L restrains the progression of replication forks and functions as a fork remodeler in human cancer cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Repair Mechanisms
Share to Genomics and Chromatin Dynamics
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39315725
DOI: 10.1093/nar/gkae828

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disparate requirements for RAD54L in replication fork reversalPMID 39315725Read ↗

Sequential role of RAD51 paralog complexes in replication fork remodeling and restart.Semantic proximity Read ↗

Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments.Semantic proximity Read ↗

Replication Fork Reversal and ProtectionSemantic proximity Read ↗

RAD51AP1 and RAD54L Can Underpin Two Distinct RAD51-Dependent Routes of DNA Damage Repair via Homologous RecombinationSemantic proximity Read ↗

RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.Semantic proximity Read ↗

Potential Rad54 separation of function mutation highlights unique roles during homologous recombination.Semantic proximity Read ↗

Fanconi-Anemia-Associated Mutations Destabilize RAD51 Filaments and Impair Replication Fork Protection.Semantic proximity Read ↗

Non-enzymatic roles of human RAD51 at stalled replication forksSemantic proximity Read ↗

The translocation activity of Rad54 reduces crossover outcomes during homologous recombinationSemantic proximity Read ↗

Analyses of the yeast Rad51 recombinase A265V mutant reveal different in vivo roles of Swi2-like factors.Semantic proximity Read ↗

RAD-ical New Insights into RAD51 RegulationSemantic proximity Read ↗

Cockayne syndrome group B protein regulates fork restart, fork progression and MRE11-dependent fork degradation in BRCA1/2-deficient cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.