Article

Distinct roles of the two BRCA2 DNA binding domains in DNA damage repair and replication fork preservation

2024-09-26

Abstract excerpt

Homologous recombination (HR) is a highly conserved tool for the removal of DNA double-strand breaks (DSBs) and the preservation of stalled and damaged DNA replication forks. Successful completion of HR requires the tumor suppressor BRCA2. Germline mutations in BRCA2 lead to familial breast, ovarian, and other cancers, underscoring the importance of this protein for maintaining genome stability. BRCA2 harbors two...

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Literature Corpus work: 26642077-f169-52d1-948b-aefd721cdcf5
DOI: 10.1101/2024.09.24.614752

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