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Article

U2AF65-Dependent SF3B1 Function in SMN Alternative Splicing

9 Dec 2020

Abstract excerpt

Splicing factor 3b subunit 1 (SF3B1) is an essential protein in spliceosomes and mutated frequently in many cancers. While roles of SF3B1 in single intron splicing and roles of its cancer-linked mutant in aberrant splicing have been identified to some extent, regulatory functions of wild-type SF3B1 in alternative splicing (AS) are not well-understood yet. Here, we applied RNA sequencing (RNA-seq) to analyze...

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PMID: 33317029
DOI: 10.3390/cells9122647

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