Article

Alternative splicing reshapes protein interaction networks through structured, directional rewiring across cancers

2026-06-25

Abstract excerpt

Alternative splicing generates extensive transcript diversity in cancer, but whether the resulting changes to protein-protein interaction (PPI) networks are structured across tumors or idiosyncratic to individual patients remains unresolved. Existing analyses catalog splicing events and their effects on individual interactions, but do not reconstruct patient-specific interaction networks at scale, leaving the syst...

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Literature Corpus work: d7165cbe-ffc4-5096-ac4f-17b3c417be2b
DOI: 10.64898/2026.06.24.734271

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