Article
Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape.
Molecular cell - 18 Apr 2024
Boddu Prajwal C, Gupta Abhishek K, Roy Rahul, De La Peña Avalos Bárbara, Olazabal-Herrero Anne, Neuenkirchen Nils, Zimmer Joshua T, Chandhok Namrata S, King Darren, Nannya Yasuhito, Ogawa Seishi, Lin Haifan, Simon Matthew D, Dray Eloise, Kupfer Gary M, Verma Amit, Neugebauer Karla M, Pillai Manoj M
Abstract excerpt
Transcription and splicing of pre-messenger RNA are closely coordinated, but how this functional coupling is disrupted in human diseases remains unexplored. Using isogenic cell lines, patient samples, and a mutant mouse model, we investigated how cancer-associated mutations in SF3B1 alter transcription. We found that these mutations reduce the elongation rate of RNA polymerase II (RNAPII) along gene bodies and...
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