Article
Temporal expression profiling identifies pathways mediating effect of causal variant on phenotype.
PLoS genetics - 1 Jun 2015
Gupta Saumya, Radhakrishnan Aparna, Raharja-Liu Pandu, Lin Gen, Steinmetz Lars M, Gagneur Julien, Sinha Himanshu
Abstract excerpt
Even with identification of multiple causal genetic variants for common human diseases, understanding the molecular processes mediating the causal variants' effect on the disease remains a challenge. This understanding is crucial for the development of therapeutic strategies to prevent and treat disease. While static profiling of gene expression is primarily used to get insights into the biological bases of...
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