Article
Genotype-environment interactions reveal causal pathways that mediate genetic effects on phenotype.
PLoS genetics - 1 Jan 2013
Gagneur Julien, Stegle Oliver, Zhu Chenchen, Jakob Petra, Tekkedil Manu M, Aiyar Raeka S, Schuon Ann-Kathrin, Pe'er Dana, Steinmetz Lars M
Abstract excerpt
Unraveling the molecular processes that lead from genotype to phenotype is crucial for the understanding and effective treatment of genetic diseases. Knowledge of the causative genetic defect most often does not enable treatment; therefore, causal intermediates between genotype and phenotype constitute valuable candidates for molecular intervention points that can be therapeutically targeted. Mapping genetic...
Topics
- Bayes Theorem
- Environment
- Gene Expression
- Gene-Environment Interaction
- Genotype
- Humans
- Metabolic Networks and Pathways
- Models, Statistical
- Phenotype
- Quantitative Trait Loci