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Article

Structural and functional mapping of Rtg2p determinants involved in retrograde signaling and aging of Saccharomyces cerevisiae.

PloS one - 1 Jan 2017

Rios-Anjos Rafaela Maria, Camandona Vittoria de Lima, Bleicher Lucas, Ferreira-Junior Jose Ribamar

Abstract excerpt

In Saccharomyces cerevisiae mitochondrial dysfunction induces retrograde signaling, a pathway of communication from mitochondria to the nucleus that promotes a metabolic remodeling to ensure sufficient biosynthetic precursors for replication. Rtg2p is a positive modulator of this pathway that is also required for cellular longevity. This protein belongs to the ASKHA superfamily, and contains a putative N-terminal...

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PMID: 28472157
DOI: 10.1371/journal.pone.0177090
PMCID: PMC5417653

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