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Article

The retrograde response links metabolism with stress responses, chromatin-dependent gene activation, and genome stability in yeast aging.

Gene - 18 Jul 2005

Jazwinski S Michal

Abstract excerpt

Yeast can be used as a model to understand the impact mitochondria have on aging in higher organisms. Mitochondrial dysfunction increases with replicative age in yeast, and this is associated with the induction of the retrograde response. This intracellular signaling pathway from the mitochondrion to the nucleus results in changes in the expression of metabolic and stress genes, which adapt the yeast cell to the...

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Identifiers

PMID: 15890475
DOI: 10.1016/j.gene.2005.03.040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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