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Mutations in <i>panD</i> encoding aspartate decarboxylase are associated with pyrazinamide resistance in <i>Mycobacterium tuberculosis</i>

1 Jan 2013

Abstract excerpt

Pyrazinamide (PZA) is a frontline anti-tuberculosis drug that plays a crucial role in the treatment of both drug susceptible and multidrug-resistant tuberculosis (MDR-TB). Resistance to PZA is most commonly associated with mutations in the pncA gene encoding nicotinamidase/pyrazinamidase which converts the prodrug PZA to the active form pyrazinoic acid (POA). RpsA (ribosomal protein S1) involved in...

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PMID: 26038471
DOI: 10.1038/emi.2013.38

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