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Identification of novel mutations in LprG <i>(rv1411c), rv0521, rv3630, rv0010c, ppsC, cyp128</i> associated with pyrazinoic acid/pyrazinamide resistance in <i>Mycobacterium tuberculosis</i>

2018-01-17

Abstract excerpt

There is currently considerable interest in understanding the mechanisms of action of pyrazinamide (PZA), a critical frontline tuberculosis (TB) drug that plays a unique role in shortening TB therapy due to its unique activity against Mycobacterium tuberculosis persisters that are not killed by other TB drugs. 1,2 Despite the importance of PZA in the treatment of both drug susceptible and drug-resistant TB and i...

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Literature Corpus work
72401944-6081-5844-b1be-ce31b3020bb0
DOI
10.1101/249201
Open publication

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