Article
A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis.
Scientific reports - 19 Jun 2017
Ramirez-Busby S M, Rodwell T C, Fink L, Catanzaro D, Jackson R L, Pettigrove M, Catanzaro A, Valafar F
Abstract excerpt
Pyrazinamide (PZA) is an important first-line drug in all existing and new tuberculosis (TB) treatment regimens. PZA-resistance in M. tuberculosis is increasing, especially among M/XDR cases. Noted issues with PZA Drug Susceptibility Testing (DST) have driven the search for alternative tests. This study provides a comprehensive assessment of PZA molecular diagnostics in M/XDR TB cases. A set of 296, mostly XDR,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.