Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis.

doi:10.1161/CIRCRESAHA.117.305875

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Article

Genetic Analysis Reveals a Longevity-Associated Protein Modulating Endothelial Function and Angiogenesis.

Circulation research - 31 Jul 2015

Villa Francesco, Carrizzo Albino, Spinelli Chiara C, Ferrario Anna, Malovini Alberto, Maciąg Anna, Damato Antonio, Auricchio Alberto, Spinetti Gaia, Sangalli Elena, Dang Zexu, Madonna Michele, Ambrosio Mariateresa, Sitia Leopoldo, Bigini Paolo, Calì Gaetano, Schreiber Stefan, Perls Thomas, Fucile Sergio, Mulas Francesca, Nebel Almut, Bellazzi Riccardo, Madeddu Paolo, Vecchione Carmine, Puca Annibale A

Abstract excerpt

RATIONALE: Long living individuals show delay of aging, which is characterized by the progressive loss of cardiovascular homeostasis, along with reduced endothelial nitric oxide synthase activity, endothelial dysfunction, and impairment of tissue repair after ischemic injury. OBJECTIVE: Exploit genetic analysis of long living individuals to reveal master molecular regulators of physiological aging and new targets...

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Identifiers

PMID: 26034043
DOI: 10.1161/CIRCRESAHA.117.305875
PMCID: PMC5496930

Genes

BPIFB4

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